Fatal variceal haemorrhage after paracetamol overdose.

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Fatal variceal haemorrhage after paracetamol overdose.

A patient is described where oesophageal varices developed and bled 13 days after a paracetamol overdose. The bleeding was unresponsive to medical management and proved fatal. There was no evidence that the patient had pre-existing liver disease. At necropsy the liver showed severe acute parenchymal necrosis but chronic lesions were absent. The portal vein and hepatic veins were patent.

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Fatal brain edema after contrast-agent overdose.

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Variceal bleeding is the most important complication of portal hypertension. Mortality due to the first variceal bleeding is very high (50%) and of those surviving a variceal bleeding episode, up to 80% may rebleed. Proper management of the acute variceal bleeding episode, the prevention of rebleeding and primary prophylaxis for variceal haemorrhage are therefore mandatory in order to improve t...

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ژورنال

عنوان ژورنال: Gut

سال: 1989

ISSN: 0017-5749

DOI: 10.1136/gut.30.10.1424